Summary for peptidase S01.236: kallikrein-related peptidase 6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namekallikrein-related peptidase 6
Other namesBSSP, kallikrein 6, KLK6 g.p. (Homo sapiens), mouse serine peptidase 18, protease M, kallikrein hK6, kallikrein 29 [obs.], myelencephalon-specific protease, MSP, neurosin, PRSS9 [obs.] g.p. (Homo sapiens), Prss18 g.p. (Mus musculus), zyme
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.236
Holotypekallikrein-related peptidase 6 (Mus musculus) (peptidase unit: 48-270), MERNUM MER0004505
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00322
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (18 cleavages)
Activity statushuman: active (Magklara et al., 2003)
mouse: active (Matsui et al., 2000)
SpecificityAn arginine-specific serine endopeptidase (Magklara et al., 2003).
PhysiologyIt is reported that neurosin has the capacity to degrade myelin-associated and other extracellular matrix proteins, and is abundantly expressed in inflammatory cells at sites of demyelination in a model of multiple sclerosis. Therefore has the potential to play a key role in immune-mediated demyelination (Blaber et al.., 2004).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/KLK6
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/RScissile bonds/a/-/g (based on 82 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 12 13 1 6 4 11 22
Pro 5 4 12 1 2 2 6 3
Ala 8 5 5 0 3 14 3 3
Val 3 4 7 0 2 12 1 2
Leu 4 6 7 2 4 6 4 4
Ile 5 2 0 0 6 4 4 2
Met 0 2 0 0 4 0 4 0
Phe 3 4 9 1 3 4 2 1
Tyr 3 0 1 1 2 1 3 1
Trp 1 0 1 0 0 1 2 3
Ser 10 6 12 2 20 10 6 0
Thr 5 4 5 1 4 1 2 3
Cys 0 0 1 0 0 0 0 0
Asn 1 1 1 0 3 1 5 2
Gln 2 6 2 0 0 1 2 2
Asp 4 6 2 0 3 5 5 2
Glu 3 4 0 0 1 0 1 2
Lys 2 6 1 10 0 0 1 0
Arg 1 4 1 63 1 1 2 1
His 3 3 1 0 3 0 3 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
KLK6 19q13.3-q13.4 ENSG00000167755 5653 KLK6 602652
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Prss18 7 ENSMUSG00000050063 19144 MGI:1343166