Summary for peptidase S01.244: kallikrein-related peptidase 8

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namekallikrein-related peptidase 8
Other namesbsp1 (Rattus norvegicus), kallikrein 8, kallikrein-8 (Homo sapiens), kallikrein hK8, kallikrein-related peptidase 8, KLK8 g.p. (Homo sapiens), neuropsin, ovasin, PRSS19 [obs.] g.p. (Homo sapiens), Prss19 g.p. (Mus musculus), TADG-14, tumor-associated differentially expressed gene 14
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.244
Holotypekallikrein-related peptidase 8 (Mus musculus), Uniprot accession Q61955 (peptidase unit: 85-309), MERNUM MER0003631
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00325
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.118
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Kishi & Diamandis, 2004)
mouse: active (Kato et al., 2001)
PhysiologyNeuropsin is essential for early processes of memory acquisition in mice (Tamura et al., 2005).
KnockoutWork with neuropsin knockout mice suggested that the enzyme is involved in connectivity of certain synapses and consequently in the hippocampal networking (Hirata et al., 2001). The enzyme seems to play a role in limiting neuronal hyperexcitability induced by epileptogenic insult (Davies et al., 2001).
Pharmaceutical relevanceNeuropsin appears to be a key protein controlling pathogenic events in the hippocampus, and thus neuropsin is a potential drug target for epilepsy (Momota et al., 1998). The enzyme has been found to be strongly over-expressed in cervical and ovarian carcinomas, so may be of diagnostic value (Kishi et al., 2003; Cane et al., 2004).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/KLK8
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/RScissile bondIa/vi/gn/G (based on 25 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 2 3 0 0 1 5 8
Pro 1 1 5 0 0 0 0 0
Ala 3 0 0 0 2 1 0 1
Val 0 2 1 0 0 4 1 0
Leu 0 3 2 0 1 0 0 0
Ile 3 0 0 0 7 3 0 1
Met 0 0 0 0 0 0 0 0
Phe 0 1 2 0 0 1 0 0
Tyr 0 0 0 0 0 0 0 1
Trp 0 0 0 0 0 0 0 0
Ser 1 2 5 0 0 0 0 0
Thr 1 1 3 0 1 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 1 0 0 0 2 0
Gln 0 4 0 0 0 0 1 0
Asp 0 3 0 0 0 0 0 0
Glu 1 3 0 0 0 0 0 0
Lys 0 0 1 4 0 1 1 0
Arg 0 0 2 21 0 0 0 0
His 0 0 0 0 0 0 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
KLK8 19q13.3-q13.4 ENSG00000160327 11202 KLK8 605644
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Prss19 7:B2 ENSMUSG00000047884 259277 MGI:1343327