Summary for peptidase S01.258: trypsin-2 type A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors Pharma


MEROPS Nametrypsin-2 type A
Other namesanionic trypsin (Homo sapiens), PRSS2 g.p. (Homo sapiens), trypsin 2, trypsinogen-2 (Homo sapiens), trypsin 8 (Homo sapiens), tumor-associated trypsin-2
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.258
Holotypetrypsin-2 type A (Homo sapiens), Uniprot accession P07478 (peptidase unit: 24-246), MERNUM MER0000021
History Identifier created: MEROPS 3.1 (22 December 1998)
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Pharmaceutical relevanceMeasurement of the concentration of trypsinogen 2 in urine may allow rapid detection of acute panreatitis (Lempinen et al., 2001).
Pathways KEGGInfluenza A
KEGGNeuroactive ligand-receptor interaction
KEGGPancreatic secretion
KEGGProtein digestion and absorption
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PRSS2 7q35 ENSG00000173636 5645 PRSS2 601564