Summary for peptidase S01.269: glutamyl endopeptidase I

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Nameglutamyl endopeptidase I
Other namesendopeptidase Glu-C, endoprotease Glu-C, endoproteinase Glu-C, Esp peptidase (Staphylococcus epidermidis), GluSE (Staphylococcus epidermidis), GluSW (Staphylococcus warneri), GluV8 (Staphylococcus aureus), gseA g.p. (Staphylococcus epidermidis), staphylococcal serine proteinase, Staphylococcus str. V8 serine endopeptidase, Spase, sspA g.p. (Staphylococcus aureus)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily B >> S01.269
Holotypeglutamyl endopeptidase I (Staphylococcus aureus), Uniprot accession P0C1U8 (peptidase unit: 69-336), MERNUM MER0000264
History Identifier created: MEROPS 3.30 (20 July 1999)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00332
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.19
EnzymologyBRENDA database
Proteolytic eventsCutDB database (21 cleavages)
BiotechnologyUsed in selective hydrolysis of proteins.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/EScissile bond-/-/-/- (based on 1405 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 95 83 62 14 136 153 100 77
Pro 82 40 82 0 0 22 98 67
Ala 129 97 111 16 153 165 125 112
Val 109 116 93 2 108 115 109 107
Leu 92 125 149 2 149 174 116 160
Ile 51 89 78 0 123 75 105 99
Met 19 32 26 1 68 44 27 32
Phe 35 45 44 1 70 58 40 45
Tyr 50 29 42 0 25 43 17 30
Trp 7 14 7 0 10 9 7 13
Ser 69 70 68 0 119 68 76 94
Thr 96 110 80 1 98 88 77 70
Cys 23 28 21 0 14 14 16 19
Asn 41 45 37 0 50 43 50 82
Gln 47 68 57 14 61 70 90 74
Asp 61 68 81 115 59 53 67 90
Glu 69 65 126 1236 24 70 77 74
Lys 90 81 116 0 59 78 98 103
Arg 26 56 38 3 40 34 45 30
His 37 44 26 0 37 27 58 19