Summary for peptidase S01.273: DegP peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS NameDegP peptidase
Other nameshigh temperature requirement A peptidase, HtrA, protease Do
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily C >> S01.273
HolotypeDegP peptidase (Escherichia coli), Uniprot accession P0C0V0 (peptidase unit: 114-269), MERNUM MER0000266
History Identifier created: MEROPS 3.30 (20 July 1999)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00333
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyA heat-shock protein in E. coli that is required for growth at elevated temperatures, probably funtioning in the degradation of unfolded proteins.
Pharmaceutical relevanceReported to be essential for the virulence of pathogenic bacteria including Salmonella enterica serovar typhimurium, Yersia entericolitica and Streptococcus pyogenes (Pallen & Wren, 1997).
Pathways KEGGTwo-component system
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/VScissile bond-/-/-/- (based on 15 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 0 1 0 0 1 1 0
Pro 0 1 2 0 0 0 0 1
Ala 3 0 1 0 2 0 0 2
Val 1 0 0 11 0 1 1 0
Leu 1 1 2 0 0 0 0 0
Ile 1 0 0 2 0 0 0 0
Met 0 0 0 0 1 1 2 1
Phe 2 0 1 0 0 1 0 1
Tyr 2 0 0 0 1 0 0 1
Trp 0 0 0 0 0 0 0 0
Ser 1 2 1 0 2 0 1 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 1 0 0 0 0
Asn 0 0 0 0 0 0 0 1
Gln 1 2 1 1 1 0 1 1
Asp 0 1 0 0 0 1 0 0
Glu 0 2 1 0 0 3 2 1
Lys 0 2 2 0 1 1 1 0
Arg 0 2 1 0 1 0 0 0
His 0 0 0 0 0 0 0 0