Summary for peptidase S01.280: lysyl endopeptidase (bacteria)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namelysyl endopeptidase (bacteria)
Other namesAchromobacter proteinase I, achromopeptidase, endopeptidase Lys-C, LepA peptidase (Lysobacter sp.), LepB peptidase (Lysobacter sp.)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily D >> S01.280
Holotypelysyl endopeptidase (bacteria) (Achromobacter lyticus), Uniprot accession P15636 (peptidase unit: 226-447), MERNUM MER0000277
History Identifier created: MEROPS 3.30 (20 July 1999)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00335
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.50
EnzymologyBRENDA database
Proteolytic eventsCutDB database (4 cleavages)
BiotechnologyUsed in amino acid sequencing of proteins.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/KScissile bond-/-/-/- (based on 809 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 46 42 52 0 44 51 39 45
Pro 45 27 50 0 1 38 36 40
Ala 53 58 55 0 72 58 49 51
Val 39 44 39 0 47 51 48 41
Leu 94 86 94 0 70 82 78 63
Ile 26 51 33 0 33 45 46 38
Met 27 33 31 0 27 24 26 21
Phe 20 27 20 0 17 27 21 30
Tyr 22 21 15 0 21 29 18 20
Trp 2 4 7 0 8 11 6 4
Ser 67 65 58 0 70 49 60 73
Thr 48 38 26 0 43 41 47 26
Cys 7 18 14 0 16 12 13 14
Asn 37 27 33 0 49 31 27 37
Gln 45 35 39 0 40 47 46 54
Asp 49 43 46 0 52 37 33 46
Glu 74 70 83 0 60 46 77 85
Lys 58 62 48 809 59 58 68 48
Arg 35 39 55 0 64 49 47 47
His 12 16 9 0 15 20 21 23