Summary for peptidase S01.281: arginyl peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namearginyl peptidase
Other namesendoproteinase Arg-C, protease IV (Pseudomonas aeruginosa), prpL endoprotease (Pseudomonas aeruginosa)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily E >> S01.281
Holotypearginyl peptidase (Lysobacter enzymogenes) (peptidase unit: 259-455), MERNUM MER0005081
History Identifier created: MEROPS 3.30 (20 July 1999)
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
KnockoutA strain of Pseudomonas aeruginosa specifically deficient in arginyl endopeptidase (as protease IV) had reduced corneal virulence (Caballero et al., 2004).
Pharmaceutical relevanceProposed to be a virulence factor in corneal infection by Pseudomonas aeruginosa (Engel et al., 1998).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/ap/p/RScissile bond-/-/al/- (based on 11 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 0 1 0 1 0 1 0
Pro 1 3 3 0 0 2 1 1
Ala 2 4 2 0 2 1 4 2
Val 2 0 0 0 0 2 0 3
Leu 2 1 2 0 0 1 3 1
Ile 0 0 0 0 0 2 0 0
Met 0 1 0 0 0 0 0 0
Phe 2 0 0 0 0 0 0 0
Tyr 0 0 0 0 0 1 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 1 0 0 2 0 1 2
Thr 0 0 2 0 1 1 0 0
Cys 0 0 1 0 0 0 0 0
Asn 0 0 0 0 0 0 0 1
Gln 0 0 0 0 1 0 1 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 1 0 0 1
Lys 0 1 0 2 3 0 0 0
Arg 1 0 0 9 0 1 0 0
His 0 0 0 0 0 0 0 0