Summary for peptidase S01.300: kallikrein-related peptidase 7

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namekallikrein-related peptidase 7
Other namesHSCCE, kallikrein 7 (Homo sapiens), kallikrein hK7, KLK7 g.p. (Homo sapiens), PRSS6 [obs.] g.p. (Homo sapiens), stratum corneum chymotryptic enzyme
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.300
Holotypekallikrein-related peptidase 7 (Homo sapiens), Uniprot accession P49862 (peptidase unit: 30-250), MERNUM MER0002001
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00336
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.117
EnzymologyBRENDA database
Proteolytic eventsCutDB database (6 cleavages)
Activity statushuman: active (Egelrud, 2004)
mouse: active (by similarity to human) (Backman et al., 1999)
PhysiologyMay play a role in desquamation of stratum corneum. Enhanced expression in inflammatory skin disease may be of etiological significance (Hansson et al., 2002).
Pharmaceutical relevanceA genetic association between an AACC insertion in the 3"UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis has been reported by Vasilopoulos et al., 2004, suggesting that the enzyme could have an important role in the development of atopic dermatitis.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/KLK7
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterni/-/-/fryScissile bond-/v/g/g (based on 17 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 2 0 0 0 1 4 4
Pro 0 0 2 0 0 1 1 0
Ala 2 2 1 0 1 0 0 2
Val 0 0 0 0 0 4 0 1
Leu 1 1 2 1 2 0 0 1
Ile 4 1 0 0 3 1 1 0
Met 0 0 0 0 0 0 0 0
Phe 0 1 4 6 1 0 0 0
Tyr 1 0 0 4 1 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 3 0 0 0 2 1
Thr 0 0 1 0 1 1 0 0
Cys 0 0 0 0 0 0 0 0
Asn 1 0 0 0 0 0 1 0
Gln 0 3 0 0 0 0 0 1
Asp 0 2 2 0 0 0 1 0
Glu 1 0 1 0 0 0 0 0
Lys 0 2 0 0 1 1 2 2
Arg 1 1 0 6 2 3 0 0
His 0 0 1 0 0 1 0 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
KLK7 19q13.3-q13.4 ENSG00000169035 5650 KLK7 604438
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Klk7 7:B2 ENSMUSG00000030713 23993 MGI:1346336