Summary for peptidase S01.302: matriptase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namematriptase
Other namesbreast cancer 80 kDa protease, CAP3, channel-activating protease 3, epithin, matriptase-1, membrane-type serine protease 1, MT-SP1, serine endopeptidase SNC19, serine protease TADG-15, PRSS14 [obs.] g.p. (Homo sapiens), ST14 g.p. (Homo sapiens), suppression of tumorigenicity-14
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.302
Holotypematriptase (Homo sapiens), Uniprot accession Q9Y5Y6 (peptidase unit: 615-855), MERNUM MER0003735
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00337
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
Activity statushuman: active (Lin et al., 2004)
mouse: active (Cho et al., 2001)
PhysiologyMatriptase is a type II transmembrane serine peptidase.
KnockoutMice deficient in matriptase die shortly after birth, showing major epidermal abnormalities, and also a dramatically increased thymocyte apoptosis (List et al., 2002).
Pharmaceutical relevanceA drug target for some forms of cancer (Galkin et al., 2004). In vitro inhibition of matriptase prevents invasive growth of certain cell lines (Forbs et al., 2005).
Other databases TREEFAMhttp://www.treefam.org/family/TF330647
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternr/-/-/RScissile bondk/v/-/g (based on 112 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 7 18 1 8 11 21 22
Pro 5 5 9 0 0 4 7 14
Ala 10 13 19 0 10 12 6 8
Val 3 8 6 0 12 26 11 9
Leu 8 8 13 1 5 15 8 9
Ile 9 4 3 0 4 6 9 13
Met 0 2 1 0 0 0 3 0
Phe 3 4 5 0 0 1 2 0
Tyr 3 2 3 0 1 2 0 0
Trp 1 0 0 0 0 0 0 0
Ser 3 7 4 0 7 2 10 5
Thr 5 8 2 0 4 8 4 3
Cys 0 2 1 0 1 0 0 2
Asn 2 4 5 1 1 6 5 2
Gln 0 19 4 0 5 6 6 4
Asp 0 0 2 0 0 3 2 5
Glu 0 2 0 0 0 0 0 1
Lys 10 7 8 5 35 0 7 5
Arg 22 6 5 103 9 0 1 1
His 4 1 1 1 1 1 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ST14 11q24-q25 ENSG00000149418 6768 ST14 606797
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
St14 9:A4 ENSMUSG00000031995 19143 MGI:1338881