Summary for peptidase S06.001: IgA1-specific serine peptidase (Neisseria-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates


MEROPS NameIgA1-specific serine peptidase (Neisseria-type)
Other namesIgA protease (Neisseria), igaB g.p. (nontypeable Haemophilus influenzae)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S6 >> Subfamily (none) >> S06.001
HolotypeIgA1-specific serine peptidase (Neisseria-type) (Neisseria gonorrhoeae), Uniprot accession P09790 (peptidase unit: 28-823), MERNUM MER0000278
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00339
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (3 cleavages)
Pharmaceutical relevanceMay allow organism to evade immune response by degrading host IgA1, particularly in meningitis. However, the role of the enzyme in allowing the organism to survive in the human host has been questioned.