Summary for peptidase S06.006: Hap serine peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates


MEROPS NameHap serine peptidase
Other namesHaemophilus adhesion and penetration protein, App g.p. (Neisseria meningitidis), Hap g.p. (Haemophilus influenzae
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S6 >> Subfamily (none) >> S06.006
HolotypeHap serine peptidase (Haemophilus influenzae), Uniprot accession P45387 (peptidase unit: 26-746), MERNUM MER0001843
History Identifier created: MEROPS 5.61 (29 October 2001)
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (4 cleavages)
PhysiologyThe non-pilus adhesin by which the bacteria adhere to host epithelial cells and form microcolonies, a member of the autotransporter family of secreted proteins expressed by gram-negative bacteria. Reported to be cleaved and inactivated by lactoferrin.