Summary for peptidase S08.007: thermitase

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namethermitase
Other namesthermophilic Streptomyces serine proteinase
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.007
Holotypethermitase (Thermoactinomyces vulgaris), Uniprot accession P04072 (peptidase unit: 8-278), MERNUM MER0000333
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00344
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.66
EnzymologyBRENDA database
Proteolytic eventsCutDB database (8 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/a/-Scissile bond-/-/-/- (based on 13 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 2 2 0 1 0 1 1
Pro 1 0 1 0 0 1 1 1
Ala 0 4 4 3 1 0 1 1
Val 2 1 0 0 1 0 2 0
Leu 1 0 0 2 1 3 0 1
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 1 1 2 3 1 1 1 0
Tyr 0 0 0 1 2 1 0 1
Trp 0 0 0 0 0 0 0 0
Ser 0 1 0 1 0 0 0 1
Thr 0 0 0 0 1 1 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 1 1 0 0 0 0 0
Gln 0 0 1 1 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 1 1 1 0 0 1 0 1
Lys 0 0 0 0 0 0 1 1
Arg 1 1 0 1 0 0 0 0
His 0 0 1 1 2 0 0 0