Summary for peptidase S08.019: lactocepin I

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

 

Names
MEROPS Namelactocepin I
Other namesCEP, extracellular lactococcal proteinase, lactococcal cell envelope-associated proteinase, lactococcal cell wall-associated proteinase, lactococcal proteinase, PrtP peptidase (Lactococcus sp.)
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.019
Holotypelactocepin I (Lactococcus lactis), Uniprot accession P16271 (peptidase unit: 176-636), MERNUM MER0000351
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00346
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.96
EnzymologyBRENDA database
BiotechnologyRole in digestion of caseins by lactobacilli in cheese making.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 102 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 2 1 1 2 1 2 3
Pro 20 22 22 19 14 19 20 22
Ala 5 4 2 4 6 2 3 3
Val 8 8 10 8 7 11 9 10
Leu 11 10 14 14 9 12 11 6
Ile 3 3 5 2 6 3 6 2
Met 2 3 4 4 2 2 6 5
Phe 7 3 8 5 4 5 4 5
Tyr 4 3 1 6 4 3 3 4
Trp 1 1 0 0 0 1 1 0
Ser 8 8 6 4 9 8 6 5
Thr 2 5 5 4 7 4 5 5
Cys 0 0 0 0 0 0 0 0
Asn 1 2 1 5 1 1 2 1
Gln 10 9 10 12 10 10 7 13
Asp 3 2 1 1 3 2 1 2
Glu 4 6 4 2 5 5 5 6
Lys 5 3 5 5 6 5 5 3
Arg 3 2 1 1 2 2 1 1
His 1 5 1 5 3 4 2 2