Summary for peptidase S08.020: C5a peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates


MEROPS NameC5a peptidase
Other namesscpA g.p. (Streptococcus pyogenes), scpB g.p. (Streptococcus agalaciae)
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.020
HolotypeC5a peptidase (Streptococcus pyogenes), Uniprot accession P15926 (peptidase unit: 50-570), MERNUM MER0000349
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00347
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
PhysiologyDestroys complement component C5a, apparently aiding organism to evade host immune response.
Pharmaceutical relevanceProposed target for vaccine against group B streptococcal infection (Cheng et al., 2002).