Summary for peptidase S08.024: dentilisin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namedentilisin
Other namesCTLP, membrane-associated chymotrypsin-like protease, PrtP g.p. (Treponema denticola), trepolisin
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.024
Holotypedentilisin (Treponema denticola) (peptidase unit: 161-640), MERNUM MER0002739
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00348
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
PhysiologyThought to contribute to pathogenesis of periodontal disease caused by the organism.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternakq/a/p/fScissile bondg/l/-/- (based on 17 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 2 0 0 4 0 0 0
Pro 0 0 5 0 0 2 0 0
Ala 4 6 2 2 0 0 0 0
Val 0 1 2 1 0 0 1 0
Leu 1 0 0 1 0 3 1 1
Ile 1 1 2 2 0 2 1 1
Met 0 0 0 0 0 0 2 0
Phe 0 0 2 7 1 1 1 1
Tyr 0 0 1 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 1
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 3 2 0 1 1 0 0 1
Asp 0 0 1 0 1 0 0 0
Glu 0 2 0 0 0 0 1 0
Lys 3 0 1 2 0 1 2 1
Arg 2 2 0 1 2 2 1 1
His 0 1 0 0 2 0 0 1