Summary for peptidase S08.034: subtilisin BPN’

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namesubtilisin BPN’
Other namesBacillus amyloliquefaciens subtilisin, Bace16 peptidase (Bacillus sp. B16), BAS, bacterial protease Novo, BLG4 cuticle-degrading peptidase (Brevibacillus laterosporus), furilysin, Genenase, Nagarse, Novozym FM, subtilopeptidase B, subtiligase, subtilopeptidase C, subtilisin B, subtilisin Novo
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.034
Holotypesubtilisin BPN’ (Bacillus amyloliquefaciens), Uniprot accession P00782 (peptidase unit: 108-382), MERNUM MER0000311
History Identifier created: MEROPS 5.5 (16 June 2001)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00349
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.62
EnzymologyBRENDA database
Proteolytic eventsCutDB database (7 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/vp/g (based on 17 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 1 1 0 0 0 2 4
Pro 1 0 0 0 0 1 3 1
Ala 1 3 4 1 1 2 2 1
Val 1 1 1 1 4 3 4 1
Leu 1 2 1 4 2 3 0 1
Ile 0 0 1 0 0 0 0 0
Met 1 0 0 1 1 0 0 1
Phe 2 1 2 1 0 0 0 0
Tyr 0 0 1 3 2 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 1 4 0 2 2 1 0 0
Thr 2 0 1 1 1 2 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 2 0 0 0 0 0
Gln 0 0 1 1 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 1 1 0 1 0 1 0 3
Lys 0 2 0 0 1 0 1 3
Arg 1 0 1 1 0 1 0 0
His 1 1 1 0 2 1 1 0