Summary for peptidase S08.051: aqualysin 1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Nameaqualysin 1
Other namescaldolysin (Thermus aquaticus strain T351), protease PA720 (Streptomyces rutgersensis)
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.051
Holotypeaqualysin 1 (Thermus aquaticus), Uniprot accession P08594 (peptidase unit: 128-453), MERNUM MER0000325
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00351
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (9 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/l/-/- (based on 11 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 2 0 1 1 0 3
Pro 0 0 2 0 0 0 1 1
Ala 1 2 1 0 2 0 0 0
Val 1 1 2 0 0 1 2 0
Leu 1 2 1 2 1 4 0 1
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 1 0 1 3 1 0 0 0
Tyr 2 0 0 1 2 1 1 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 1 0 0 1 0
Thr 0 1 0 0 0 1 1 0
Cys 0 0 0 0 0 0 0 0
Asn 1 0 1 0 0 0 0 0
Gln 0 1 0 1 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 2 1 0 1 0 1 0 1
Lys 0 0 0 1 0 0 0 1
Arg 1 1 0 0 0 0 1 0
His 1 0 1 0 2 0 0 1