Summary for peptidase S08.052: cerevisin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namecerevisin
Other namesalkaline proteinase (Penicillium citrinum), allergen Pen c 2 (Penicillium citrinum), allergen Rho m 2 (Rhodotorula mucilaginosa), antigen Pen c 2 (Penicillium citrinum), antigen Pen o 18 (Penicillium oxalicum), antigen Pen c 18 (Penicillium citrinum), antigen Pen ch 18 (Penicillium chrysogenum), Evsp peptidase (Esteya vermicola), Isp6 protein (Schizosaccharomyces pombe), PRB1 g.p. (Saccharomyces cerevisiae), proteinase yscB (Saccharomyces cerevisiae), proteinase B (Saccharomyces cerevisiae), Psp1 g.p. (Pyrenopeziza brassicae), SPMI g.p. (Magnaporthe grisea), SL41 g.p. (Trichoderma harzianum)
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.052
Holotypecerevisin (Saccharomyces cerevisiae), Uniprot accession P09232 (peptidase unit: 269-635), MERNUM MER0000356
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00352
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.48
EnzymologyBRENDA database
Proteolytic eventsCutDB database (9 cleavages)
PhysiologyProcesses precursors of other proteins in yeast vacuole.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/rlyScissile bond-/-/-/- (based on 20 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 3 2 0 1 0 1 2
Pro 0 0 0 0 0 0 1 1
Ala 1 1 1 0 0 2 1 0
Val 1 1 0 0 2 1 1 0
Leu 2 1 1 4 1 2 0 1
Ile 1 0 1 0 0 0 0 0
Met 0 0 2 0 0 0 0 0
Phe 1 0 1 2 3 1 1 0
Tyr 0 0 1 4 2 1 0 2
Trp 1 2 0 0 0 0 0 0
Ser 0 1 0 0 0 0 0 0
Thr 0 1 0 0 0 1 1 0
Cys 0 1 0 0 0 0 0 0
Asn 0 0 1 0 0 0 1 0
Gln 0 1 0 1 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 2 2 1 0 1 1 0 1
Lys 0 0 2 1 0 0 0 1
Arg 2 1 1 8 0 0 0 0
His 0 0 1 0 1 1 0 0