Summary for peptidase S08.054: endopeptidase K

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Nameendopeptidase K
Other namesproteinase K, Tritirachium alkaline proteinase
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.054
Holotypeendopeptidase K (Engyodontium album), Uniprot accession P06873 (peptidase unit: 106-384), MERNUM MER0000335
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00354
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.64
EnzymologyBRENDA database
Proteolytic eventsCutDB database (5 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternv/-/-/-Scissile bond-/-/-/- (based on 47 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 6 7 7 4 5 4 5 8
Pro 1 0 2 0 0 1 2 1
Ala 5 4 9 5 4 2 3 2
Val 10 5 5 1 6 4 4 3
Leu 3 4 3 5 5 8 2 2
Ile 4 2 3 1 1 3 4 2
Met 0 1 0 2 0 0 0 1
Phe 4 2 2 3 1 1 3 2
Tyr 4 0 1 3 2 2 1 2
Trp 0 0 0 0 0 0 0 1
Ser 0 3 2 3 3 4 1 3
Thr 0 2 2 3 4 2 3 2
Cys 0 0 0 0 0 1 0 0
Asn 0 1 1 4 3 2 2 3
Gln 0 1 1 4 3 0 0 2
Asp 1 2 1 1 2 1 2 0
Glu 2 2 0 3 2 4 3 5
Lys 1 3 4 2 1 2 6 4
Arg 1 2 0 0 1 1 1 0
His 2 2 1 1 2 1 1 0