Summary for peptidase S08.063: site-1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namesite-1 peptidase
Other namesAtS1P (Arabidopsis thaliana), AtSBT6.1 (Arabidopsis thaliana), KIAA0091 putative peptidase, mammalian subtilisin/kexin isozyme 1, MBTPS1 g.p. (Homo sapiens), membrane-bound transcription factor peptidase site 1, proprotein convertase SKI-1, PS1, SKI-1 (Mus musculus), S1P protease, sterol regulatory element-binding protein site 1 protease, site-1 protease, SREBP S1 protease
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.063
Holotypesite-1 peptidase (Cricetulus griseus), Uniprot accession Q9Z2A8 (peptidase unit: 179-473), MERNUM MER0004988
History Identifier created: MEROPS 3.1 (22 December 1998)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00356
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (10 cleavages)
Activity statushuman: active (Seidah & Chretien, 2004)
mouse: active (by similarity) (Cheng et al., 1999)
Other databases TREEFAMhttp://www.treefam.org/family/TF324501
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternR/rsk/L/LScissile bondags/ft/fe/st (based on 30 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 0 0 7 0 0 0
Pro 0 0 2 0 0 0 1 1
Ala 0 0 0 2 8 2 2 2
Val 0 0 4 0 1 0 0 0
Leu 0 0 19 19 0 4 3 3
Ile 0 0 3 0 1 1 1 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 1 1 1 9 10 0
Tyr 0 0 0 0 1 2 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 6 0 0 5 1 2 11
Thr 1 2 0 1 1 6 0 6
Cys 0 1 0 0 0 0 0 0
Asn 0 3 0 0 1 0 0 0
Gln 1 2 0 1 1 0 0 0
Asp 0 0 0 0 0 1 2 3
Glu 0 0 0 0 0 1 6 1
Lys 0 4 0 4 0 1 1 1
Arg 27 10 1 1 2 0 1 1
His 0 1 0 1 0 1 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MBTPS1 16q24 ENSG00000140943 8720 MBTPS1 603355
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mbtps1 8:E1 ENSMUSG00000031835 56453 MGI:1927235