Summary for peptidase S08.070: kexin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namekexin
Other namesKEX2 g.p. (Saccharomyces cerevisiae), KexB g.p. (Aspergillus sp.), Krp1 g.p. (Schizosaccharomyces pombe), paired-basic endopeptidase, prohormone-processing endoprotease, yeast cysteine proteinase F (misleading), XPR6 g.p. (Yarrowia lipolytica)
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.070
Holotypekexin (Saccharomyces cerevisiae), Uniprot accession P13134 (peptidase unit: 144-439), MERNUM MER0000364
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00357
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.61
EnzymologyBRENDA database
Proteolytic eventsCutDB database (181 cleavages)
PhysiologyProcesses various preproteins by cleavage at paired basic amino acids.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/K/RScissile bonddae/-/-/- (based on 191 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 5 0 0 12 9 14 8
Pro 4 0 0 0 2 15 5 13
Ala 8 25 1 0 41 30 19 16
Val 11 16 1 0 1 35 37 28
Leu 35 3 0 0 3 15 6 5
Ile 13 4 0 0 1 6 9 9
Met 6 3 0 0 3 1 4 2
Phe 4 8 0 0 2 4 1 5
Tyr 1 7 0 0 4 7 2 18
Trp 0 1 0 0 0 1 1 1
Ser 5 16 2 0 16 6 15 10
Thr 5 13 3 0 1 9 2 11
Cys 0 2 0 0 1 1 1 2
Asn 26 9 0 0 4 9 12 11
Gln 15 7 0 0 7 3 6 9
Asp 1 13 1 0 57 20 18 15
Glu 6 18 2 0 32 12 13 12
Lys 28 13 168 1 0 3 14 8
Arg 9 6 13 190 0 2 1 1
His 10 22 0 0 2 1 9 5