Summary for peptidase S08.073: PCSK2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS NamePCSK2 peptidase
Other namesAmontillado protein (Drosophila melanogaster), neuroendocrine convertase 2 (NEC2), PC2, SPC2, PCSK2 g.p. (Homo sapiens), proprotein convertase 2, proprotein convertase subtilisin/kexin type 2
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.073
HolotypePCSK2 peptidase (Homo sapiens), Uniprot accession P16519 (peptidase unit: 142-439), MERNUM MER0000377
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00360
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.94
EnzymologyBRENDA database
Proteolytic eventsCutDB database (41 cleavages)
Activity statushuman: active (Seidah & Chretien, 2004)
mouse: active (Berman et al., 2000)
PhysiologyProcesses various preproteins by cleavage at paired basic amino acids.
KnockoutKnockout mice were produced by Furuta et al. (1997), and were found to be viable. Such mice were later reported to have severely abnormal processing of dynorphin peptides (Berman et al., 2000).
Other databases TREEFAMhttp://www.treefam.org/family/TF314277
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternr/-/Kr/RScissile bond-/-/-/- (based on 202 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 13 0 0 15 23 31 13
Pro 4 3 9 0 6 14 11 15
Ala 4 9 6 0 20 22 7 10
Val 11 8 2 0 2 27 10 6
Leu 9 15 5 0 6 22 11 14
Ile 10 3 1 0 3 16 6 2
Met 7 3 0 0 1 2 1 8
Phe 6 6 0 1 11 5 1 18
Tyr 8 1 0 0 25 5 5 6
Trp 1 0 0 0 1 2 1 1
Ser 4 22 2 1 43 16 17 16
Thr 3 11 4 0 2 10 7 7
Cys 0 0 0 0 2 1 1 1
Asn 7 5 0 0 5 2 10 10
Gln 8 27 0 0 9 3 16 4
Asp 0 7 1 0 13 4 16 21
Glu 9 19 2 0 14 6 26 22
Lys 13 20 120 11 5 7 5 7
Arg 86 15 44 189 3 6 9 7
His 2 7 0 0 7 0 1 4
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PCSK2 20p11.2 ENSG00000125851 5126 PCSK2 162151
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pcsk2 2:F3-H2 ENSMUSG00000027418 18549 MGI:97512