Summary for peptidase S08.074: PCSK4 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Pharma

 

Names
MEROPS NamePCSK4 peptidase
Other namesneuroendocrine convertase, PC4, PCSK4, SPC5, SPSK4 g.p. (Homo sapiens), proprotein convertase 4, proprotein convertase subtilisin/kexin type 4
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.074
HolotypePCSK4 peptidase (Mus musculus), Uniprot accession P29121 (peptidase unit: 133-423), MERNUM MER0000381
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00361
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Seidah & Chretien, 2004)
mouse: active (Mbikay et al., 1997)
PhysiologyProcesses various preproteins by cleavage at paired basic amino acids.
KnockoutThe fertility of male mice with homozygous deficiency of proprotein convertase 4 was severely impaired, and there were also defects in embryonic development (Mbikay et al., 1997).
Other databases TREEFAMhttp://www.treefam.org/family/TF314277
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternR/-/KR/RScissile bonds/val/-/- (based on 103 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 4 0 0 3 4 12 8
Pro 0 0 6 0 2 4 2 11
Ala 0 5 3 0 9 19 4 5
Val 4 5 1 0 3 25 3 7
Leu 0 4 1 0 1 15 8 11
Ile 2 0 0 0 0 7 4 0
Met 0 2 0 0 1 0 0 1
Phe 1 3 0 0 6 1 2 1
Tyr 1 0 0 0 6 0 1 0
Trp 0 0 0 0 0 1 0 0
Ser 0 11 2 0 31 3 13 8
Thr 0 8 2 0 1 10 6 6
Cys 0 0 0 0 3 0 0 1
Asn 0 4 0 0 0 0 5 4
Gln 1 10 0 0 5 0 4 3
Asp 0 2 0 0 9 4 12 8
Glu 1 2 1 0 9 0 11 13
Lys 8 18 49 3 0 2 4 3
Arg 77 12 32 100 1 0 2 2
His 2 6 0 0 5 0 2 3
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PCSK4 19p13.3 ENSG00000115257 54760 PCSK4 600487
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pcsk4 10:C1 ENSMUSG00000020131 18551 MGI:97514