Summary for peptidase S08.075: PCSK6 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS NamePCSK6 peptidase
Other namesproprotein convertase PACE4, PACE4 proprotein convertase, PCSK6 g.p. (Homo sapiens), proprotein convertase 6, proprotein convertase subtilisin/kexin type 6
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.075
HolotypePCSK6 peptidase (Homo sapiens), Uniprot accession P29122 (peptidase unit: 182-473), MERNUM MER0000383
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00362
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (7 cleavages)
Activity statushuman: active (Mains, 2004)
mouse: active (by similarity to human)
PhysiologyProcesses various preproteins by cleavage at paired basic amino acids.
Other databases TREEFAMhttp://www.treefam.org/family/TF314277
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternR/-/KR/RScissile bonds/val/-/- (based on 105 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 4 0 0 3 4 15 8
Pro 0 0 6 0 2 4 2 11
Ala 0 6 3 0 10 20 4 5
Val 4 7 1 0 3 29 2 6
Leu 0 4 1 0 1 15 8 12
Ile 2 0 0 0 0 8 4 1
Met 0 2 0 0 1 0 0 2
Phe 1 3 0 0 7 1 2 1
Tyr 1 0 0 0 6 0 1 0
Trp 0 0 0 0 0 1 0 0
Ser 0 12 2 0 33 4 14 10
Thr 0 7 2 0 1 10 7 6
Cys 0 0 0 0 3 0 0 1
Asn 0 5 0 0 1 0 5 4
Gln 1 10 0 0 7 0 4 3
Asp 0 2 0 0 9 4 13 10
Glu 1 3 1 0 9 0 11 13
Lys 7 19 53 3 0 2 5 3
Arg 85 12 36 102 1 0 3 3
His 2 7 0 0 5 0 2 3
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PCSK6 15q26 ENSG00000140479 5046 PACE4 167405
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pace4 7:B5 ENSMUSG00000030513 18553 MGI:102897