Summary for peptidase S08.076: PCSK5 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS NamePCSK5 peptidase
Other namesPC5, PC5A, PC5B, PC5/6 [obs.], PC6A [obs.], PC6B [obs.], PCSK5, proprotein convertase 5, proprotein convertase 6 [obs.], proprotein convertase subtilisin/kexin type 5
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.076
HolotypePCSK5 peptidase (Rattus norvegicus), Uniprot accession P41413 (peptidase unit: 150-441), MERNUM MER0001514
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00363
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (7 cleavages)
Activity statushuman: active (Seidah & Chretien, 2004)
mouse: active (by similarity to human)
PhysiologyProcesses various preproteins by cleavage at paired basic amino acids.
KnockoutDisruption of the proprotin convertase 5 gene in mouse shows that it is essential (Essalmani et al., 2006).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternR/-/KR/RScissile bonds/val/-/- (based on 129 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 6 1 0 7 5 15 11
Pro 1 1 8 0 2 6 4 12
Ala 0 8 3 0 9 24 5 10
Val 4 4 1 0 3 25 2 7
Leu 0 6 1 0 2 22 10 13
Ile 6 3 0 0 1 9 6 1
Met 0 3 0 0 1 0 0 3
Phe 1 5 0 0 9 3 2 2
Tyr 2 0 0 0 7 0 1 1
Trp 0 0 0 0 0 1 0 0
Ser 0 16 4 0 37 5 15 9
Thr 0 8 3 0 3 12 6 9
Cys 0 0 0 0 3 0 0 1
Asn 0 5 0 0 2 0 5 4
Gln 1 10 0 0 7 0 6 4
Asp 0 2 0 0 11 5 15 8
Glu 3 5 2 0 11 1 13 15
Lys 8 23 59 4 1 8 8 5
Arg 97 13 41 125 2 0 4 4
His 3 6 1 0 8 0 3 3
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PCSK5 9 ENSG00000099139 5125 PCSK5 600488