Summary for peptidase S08.077: PCSK7 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Pharma

 

Names
MEROPS NamePCSK7 peptidase
Other namesPC7, proprotein convertase 8, PC8, LPC, lymphoma proprotein convertase, proprotein convertase subtilisin kexin 7, PCSK7 g.p. (Homo sapiens), proprotein convertase 7, proprotein convertase subtilisin/kexin type 7
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily B >> S08.077
HolotypePCSK7 peptidase (Rattus norvegicus), Uniprot accession Q62849 (peptidase unit: 155-458), MERNUM MER0002264
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00364
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (7 cleavages)
Activity statushuman: active (Seidah & Chretien, 2004)
mouse: active (by similarity to human)
PhysiologyProcesses various preproteins by cleavage at paired basic amino acids.
Other databases TREEFAMhttp://www.treefam.org/family/TF314277
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternR/-/KR/RScissile bonds/vla/-/- (based on 116 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 5 0 0 7 4 13 9
Pro 0 0 7 0 2 4 3 11
Ala 0 5 3 0 10 20 4 10
Val 4 5 1 0 3 25 3 7
Leu 0 5 1 0 1 22 8 11
Ile 5 3 0 0 0 8 6 1
Met 0 2 0 0 1 0 0 2
Phe 1 3 0 0 7 2 2 1
Tyr 1 0 0 0 6 0 1 0
Trp 0 0 0 0 0 1 0 0
Ser 0 13 2 0 34 5 13 9
Thr 1 8 2 0 1 11 6 6
Cys 0 0 0 0 4 0 1 1
Asn 0 4 0 0 0 0 5 5
Gln 1 11 0 0 5 0 5 3
Asp 0 2 0 0 10 4 14 8
Glu 1 2 2 0 11 1 13 15
Lys 9 23 54 4 0 2 4 3
Arg 85 12 38 112 2 0 2 2
His 2 6 0 0 5 0 2 3
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PCSK7 11q23-q24 ENSG00000160613 9159 PCSK7 604872
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pcsk7 9:A5.2 ENSMUSG00000035382 18554 MGI:107421