Summary for peptidase S08.092: cucumisin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namecucumisin
Other namesallergen Cuc m 1 (Cucumis melo), hordolisin, macluralisin, protease D (Cucumis melo), taraxalisin, SEP-1 endopeptidase (Hordeum vulgare)
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.092
Holotypecucumisin (Cucumis melo), Uniprot accession Q39547 (peptidase unit: 129-585), MERNUM MER0001561
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00366
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.25
EnzymologyBRENDA database
Proteolytic eventsCutDB database (20 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternl/-/p/-Scissile bonda/l/-/- (based on 31 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 2 3 2 3 2 2 3
Pro 0 0 10 1 0 1 1 1
Ala 3 7 3 3 7 1 1 1
Val 3 3 2 0 1 1 2 1
Leu 8 7 2 6 3 9 1 3
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 1 0 0 0 0
Phe 2 1 2 3 2 2 2 2
Tyr 2 1 0 2 2 2 2 1
Trp 0 0 0 0 0 0 0 0
Ser 0 1 0 1 0 1 1 1
Thr 0 1 1 1 1 1 1 1
Cys 1 2 1 2 1 1 2 1
Asn 1 1 1 1 0 0 0 0
Gln 1 1 1 2 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 2 2 2 2 1 2 0 2
Lys 0 0 0 1 1 0 1 1
Arg 1 1 1 1 1 2 3 1
His 1 1 2 1 2 0 1 1