Summary for peptidase S09.004: acylaminoacyl-peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameacylaminoacyl-peptidase
Other namesacylamino-acid-releasing enzyme, APEH g.p. (Homo sapiens), N-acylpeptide hydrolase, N-formylmethionine (fMet) aminopeptidase, oxidized protein hydrolase, OPH
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S9 >> Subfamily C >> S09.004
Holotypeacylaminoacyl-peptidase (Homo sapiens), Uniprot accession P13798 (peptidase unit: 477-728), MERNUM MER0000408
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00369
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase 3.4.19.1
EnzymologyBRENDA database
Activity statushuman: active (Manning, 2004)
mouse: active (Kobayashi et al., 1987)
Other databases TREEFAMhttp://www.treefam.org/family/TF312937
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/fahScissile bond-/-/-/- (based on 14 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 2 0 0 0 0 0
Pro 0 0 0 0 0 1 0 0
Ala 0 0 0 2 0 1 0 0
Val 0 1 2 0 0 0 0 1
Leu 0 1 0 0 0 0 1 1
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 1 0
Phe 0 0 0 4 1 0 0 0
Tyr 1 0 0 0 1 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 1 0 1 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 1 1 0 0
Asp 0 0 0 0 0 0 0 1
Glu 1 1 0 1 1 0 1 1
Lys 1 0 0 0 0 1 1 0
Arg 0 0 0 0 0 0 0 1
His 0 0 1 2 1 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
APEH 3p21 ENSG00000164062 327 APEH 102645
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Apeh 9:F2 ENSMUSG00000032590 235606 MGI:88041