Summary for peptidase S09.010: oligopeptidase B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Nameoligopeptidase B
Other namesalkaline peptidase, dipeptidyl aminopeptidase BI (Pseudomonas sp. WO24), peptidase A, oligopeptidase Tb (Trypanosoma brucei), oligopeptidase Tc (Trypanosoma congolense), oligopeptidase Tc80 (Trypanosoma cruzi), OpdB g.p. (Salmonella typhimurium), peptidase I-mes (Prosopis velutina), protease II (Escherichia coli)
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S9 >> Subfamily A >> S09.010
Holotypeoligopeptidase B (Escherichia coli), Uniprot accession P24555 (peptidase unit: 397-682), MERNUM MER0000410
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00371
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.83
EnzymologyBRENDA database
Proteolytic eventsCutDB database (8 cleavages)
Pathways KEGGAfrican trypanosomiasis
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/g/rgkfp/RScissile bond-/-/-/- (based on 42 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 7 6 0 2 0 0 2
Pro 1 2 4 1 1 1 0 0
Ala 1 2 0 0 0 0 0 0
Val 0 4 0 0 1 0 0 0
Leu 0 4 2 0 0 0 1 1
Ile 0 1 0 0 1 0 2 1
Met 0 0 0 0 0 0 0 0
Phe 1 2 4 1 1 0 1 1
Tyr 1 1 0 0 1 2 0 0
Trp 0 0 0 0 0 0 0 0
Ser 1 2 0 0 2 2 1 0
Thr 0 0 0 0 0 0 0 0
Cys 0 2 0 0 0 0 1 1
Asn 3 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 1 0 0 1 0 0
Glu 0 0 0 0 0 0 0 0
Lys 1 0 5 3 0 0 0 0
Arg 1 1 11 37 1 1 2 1
His 0 0 1 0 0 1 0 1