Summary for peptidase S10.002: serine carboxypeptidase A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameserine carboxypeptidase A
Other namescarboxypeptidase-L, carboxypeptidase Y-like kininase, cathepsin A, cathepsin I (obs.), CTSA g.p. (Homo sapiens), deamidase, HlSCP1 (Haemaphysalis longicornis), lysosomal carboxypeptidase A, lysosomal protective protein, protective protein, urinary kininase
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S10 >> Subfamily (none) >> S10.002
Holotypeserine carboxypeptidase A (Homo sapiens), Uniprot accession P10619 (peptidase unit: 39-480), MERNUM MER0000430
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00373
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.16 (Serine-type carboxypeptidases) >> Peptidase 3.4.16.5
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
Activity statushuman: active (Pshezhetsky, 2004)
mouse: active (by similarity to human) (Zhou et al., 1995)
PhysiologyReported to regulate the degradation of lysosome-associated membrane protein type-2a (lamp2a), a crucial receptor for chaperone-mediated autophagy (Cuervo et al., 2003).
KnockoutMutations in the gene encoding lysosomal carboxypeptidase A are the cause of the lysosomal disorder galactosialidosis. Human lysosomal beta-galactosidase and neuraminidase exist as a high molecular weight enzyme complex, in which there is also glycoprotein termed "lysosomal protective protein" that is identical with lysosomal carboxypeptidase A. The protective function of lysosomal carboxypeptidase A is distinct from its catalytic activity, however. Knockout mice show a phenotype similar to human galactosialidosis (Zhou et al., 1995).
Pathways KEGGLysosome
KEGGRenin-angiotensin system
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Cathepsin_A
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/FScissile bondlf/-/-/- (based on 10 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 0 0
Pro 0 1 0 0 0 0 1 0
Ala 0 0 0 0 1 0 0 0
Val 0 0 0 1 0 1 0 0
Leu 0 0 0 0 4 0 0 0
Ile 0 0 0 0 0 0 0 1
Met 0 0 0 0 0 0 0 0
Phe 0 0 1 6 2 0 0 0
Tyr 0 0 0 1 1 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 2 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 2 2 0 0 0 0 0 0
Glu 0 0 0 1 0 0 0 0
Lys 0 0 0 0 0 0 0 0
Arg 0 0 0 0 0 0 0 0
His 1 0 0 1 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CTSA 20q13.1 ENSG00000064601 5476 PPGB 256540
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ppgb 2:H3 ENSMUSG00000017760 19025 MGI:97748