Summary for peptidase S15.001: Xaa-Pro dipeptidyl-peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS NameXaa-Pro dipeptidyl-peptidase
Other namesdipeptidyl-peptidase IV (Lactococcus), PepX, PepXP, X-prolyl dipeptidyl aminopeptidase, X-Pro dipeptidyl-peptidase
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S15 >> Subfamily (none) >> S15.001
HolotypeXaa-Pro dipeptidyl-peptidase (Lactococcus lactis), Uniprot accession Q02W78 (peptidase unit: 1-763), MERNUM MER0000443
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00383
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.14 (Dipeptidyl-peptidase and tripeptidyl-peptidases) >> Peptidase 3.4.14.11
EnzymologyBRENDA database
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/PScissile bond-/-/-/- (based on 10 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 2 0 1 0 1 0
Pro 0 0 0 8 0 2 0 1
Ala 0 0 3 2 0 0 0 0
Val 0 0 0 0 0 0 0 0
Leu 0 0 0 0 0 0 0 0
Ile 0 0 0 0 1 0 1 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 1 0 1 0 0 0
Tyr 0 0 1 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 1 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 1 0 0 0 0 0
Arg 0 0 1 0 0 0 0 0
His 0 0 0 0 0 0 0 0