Summary for peptidase S21.002: cytomegalovirus assemblin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namecytomegalovirus assemblin
Other namesCMV protease, protease No, UL80 g.p. (human cytomegalovirus)
Domain architecture
MEROPS Classification
Classification Clan SH >> Subclan (none) >> Family S21 >> Subfamily (none) >> S21.002
Holotypecytomegalovirus assemblin (human herpesvirus 5), Uniprot accession P16753 (peptidase unit: 1-256), MERNUM MER0000613
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00387
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (5 cleavages)
PhysiologyPlays essential role in assembly of herpes virions by digesting scaffold protein.
Pharmaceutical relevancePotential target for antiviral drug.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternvyl/V/nk/AScissile bondS/-/sr/plv (based on 13 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 1 0 0
Pro 0 0 0 0 0 0 0 4
Ala 1 0 0 13 2 1 0 0
Val 3 12 0 0 0 3 0 1
Leu 2 0 0 0 0 0 0 3
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 0 0 0 0 0
Tyr 3 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 11 1 5 0
Thr 0 0 0 0 0 1 0 0
Cys 0 0 0 0 0 2 0 0
Asn 0 0 5 0 0 0 0 0
Gln 0 0 1 0 0 0 0 0
Asp 1 0 1 0 0 0 1 0
Glu 0 0 1 0 0 0 1 0
Lys 0 0 3 0 0 0 0 0
Arg 0 0 0 0 0 0 4 0
His 0 0 0 0 0 0 0 0