Summary for peptidase S21.003: Epstein-Barr virus-type assemblin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma


MEROPS NameEpstein-Barr virus-type assemblin
Domain architecture
MEROPS Classification
Classification Clan SH >> Subclan (none) >> Family S21 >> Subfamily (none) >> S21.003
HolotypeEpstein-Barr virus-type assemblin (human herpesvirus 4), Uniprot accession P03234 (peptidase unit: 1-235), MERNUM MER0000612
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyPlays essential role in assembly of Epstein-Barr virus virions by digesting scaffold protein.
Pharmaceutical relevancePotential target for antiviral drug. Epstein-Barr virus is the cause of a latent, asymptomatic infection in a large percentage of the population, but in young adults primary infection can result in infectious mononucleosis (glandular fever). Proteins expressed in the later, latent phase of the viral life cycle have been associated with a number of diseases including Burkitt’s lymphoma, nasopharyngeal carcinoma and Hodgkin’s disease.