Summary for peptidase S26.001: signal peptidase I

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namesignal peptidase I
Other namesleader peptidase I, leader peptidase B, LepB
Domain architecture
MEROPS Classification
Classification Clan SF >> Subclan (none) >> Family S26 >> Subfamily A >> S26.001
Holotypesignal peptidase I (Escherichia coli), Uniprot accession P00803 (peptidase unit: 78-324), MERNUM MER0000589
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00391
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.89
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
PhysiologyCleaves signal peptides from secreted proteins.
Pharmaceutical relevancePotential drug target for antibacterial agents (Barbosa et al., 2002; Kulanthaivel et al., 2004).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/A/-/AScissile bonda/ed/-/- (based on 342 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 20 2 5 10 15 20 27 14
Pro 32 0 0 1 0 30 16 33
Ala 60 221 13 318 161 15 50 28
Val 23 49 9 1 11 13 25 17
Leu 12 11 56 0 5 2 29 16
Ile 12 6 2 0 1 13 14 21
Met 6 1 17 0 1 2 4 2
Phe 7 2 57 0 5 3 7 6
Tyr 10 0 16 0 1 1 9 10
Trp 0 0 18 0 1 2 1 4
Ser 71 33 17 9 14 18 15 21
Thr 30 8 13 0 8 30 38 32
Cys 2 0 1 0 2 3 3 0
Asn 17 1 21 0 9 20 23 19
Gln 15 0 43 3 23 12 17 14
Asp 3 0 1 0 30 57 10 33
Glu 3 0 5 0 29 95 20 17
Lys 8 0 7 0 17 5 21 20
Arg 7 0 6 0 1 0 8 4
His 2 0 33 0 8 1 4 3