Summary for peptidase S26.010: signalase (animal) 21 kDa component

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates

 

Names
MEROPS Namesignalase (animal) 21 kDa component
Other namesleader peptidase, signal peptidase complex 21 kDa component, SPC21
Domain architecture
MEROPS Classification
Classification Clan SF >> Subclan (none) >> Family S26 >> Subfamily B >> S26.010
Holotypesignalase (animal) 21 kDa component (Saccharomyces cerevisiae), Uniprot accession P15367 (peptidase unit: 32-167), MERNUM MER0000602
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00394
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.89
EnzymologyBRENDA database
Activity statushuman: active (Liang et al., 2003)
mouse: active (by similarity to dog) (Liang et al., 2003)
PhysiologyCleaves signal peptides from secreted proteins cotranslationally.
Pharmaceutical relevance'The revelation of signal peptidase involved in HCV polyprotein processing presents a novel drug target to suppress HCV viral replication for the much needed HCV therapy' (Wu, 2001).
Other databases TREEFAMhttp://www.treefam.org/family/TF313648
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/avs/-/AScissile bonda/-/-/- (based on 363 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 34 10 9 46 25 37 22 23
Pro 18 3 4 6 0 30 39 39
Ala 44 117 31 200 91 29 25 24
Val 23 90 15 2 20 26 25 21
Leu 43 6 35 4 14 12 16 29
Ile 13 5 10 1 16 21 21 18
Met 12 1 6 0 2 0 1 2
Phe 8 3 22 3 11 7 13 15
Tyr 9 0 13 1 10 11 15 17
Trp 0 0 4 1 1 2 6 6
Ser 54 41 43 48 31 36 39 22
Thr 35 32 20 3 25 35 35 30
Cys 8 25 4 6 4 5 36 23
Asn 8 4 23 9 6 20 15 17
Gln 16 1 23 5 36 15 6 11
Asp 5 7 18 1 26 27 19 16
Glu 9 8 34 4 24 22 16 21
Lys 10 7 9 5 10 17 4 18
Arg 8 2 17 18 6 7 6 8
His 6 1 23 0 5 4 4 3
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
SEC11C 18q21.31 ENSG00000166562 90701
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Sec11l3 18:E1 ENSMUSG00000024516 66286 MGI:1913536