Summary for peptidase S28.001: lysosomal Pro-Xaa carboxypeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namelysosomal Pro-Xaa carboxypeptidase
Other namesacid angiotensinase, angiotensinase C, lysosomal carboxypeptidase C, prolylcarboxypeptidase, PRCP g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S28 >> Subfamily (none) >> S28.001
Holotypelysosomal Pro-Xaa carboxypeptidase (Homo sapiens), Uniprot accession P42785 (peptidase unit: 46-496), MERNUM MER0000446
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00395
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.16 (Serine-type carboxypeptidases) >> Peptidase 3.4.16.2
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Tan & Erdos, 2004)
mouse: active (by similarity to other mammals)
PhysiologyLysosomal Pro-X carboxypeptidase is reported to be a physiological activator of plasma prekallikrein (Shariat-Madar et al., 2004).
Pathways KEGGProtein digestion and absorption
Other databases TREEFAMhttp://www.treefam.org/family/TF314414
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/PScissile bondfa/-/-/- (based on 11 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 0 0 0 1 0 0 0
Pro 1 0 0 11 0 0 0 0
Ala 0 0 0 0 2 0 0 0
Val 0 0 0 0 1 0 0 0
Leu 0 0 0 0 1 0 0 0
Ile 0 3 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 1 0 0 4 0 0 0
Tyr 2 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 1 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 0 0 0 0 0
Arg 0 0 0 0 0 0 0 0
His 0 0 3 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PRCP 11q14 ENSG00000137509 5547 PRCP 176785
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
2510048K03Rik 7:D3 ENSMUSG00000041252 72461 MGI:1919711