Summary for peptidase S28.002: dipeptidyl-peptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namedipeptidyl-peptidase II
Other namescarboxytripeptidase, dipeptidyl peptidase 2, dipeptidyl aminopeptidase II, dipeptidyl arylamidase II, DPP II, dipeptidyl peptidase VII, quiescent cell proline dipeptidase, DPP7 g.p. (Homo sapiens), DPP2
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S28 >> Subfamily (none) >> S28.002
Holotypedipeptidyl-peptidase II (Rattus norvegicus), Uniprot accession Q9EPB1 (peptidase unit: 39-494), MERNUM MER0006058
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00396
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.14 (Dipeptidyl-peptidase and tripeptidyl-peptidases) >> Peptidase 3.4.14.2
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (McDonald & Ohkubo, 2004)
mouse: active (by similarity to rat) (Araki et al., 2001)
Other databases TREEFAMhttp://www.treefam.org/family/TF314414
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/PamScissile bond-/-/-/- (based on 30 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 4 0 2 1 1 0
Pro 0 0 2 18 3 3 0 1
Ala 0 0 4 7 3 0 0 0
Val 0 0 0 0 1 0 0 0
Leu 0 0 1 0 0 0 0 0
Ile 0 0 0 0 0 0 1 0
Met 0 0 2 4 1 0 0 0
Phe 0 0 2 0 1 0 2 1
Tyr 0 0 1 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 2 0 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 2 1 1 1
Asp 0 0 0 0 0 0 0 0
Glu 0 0 1 0 1 0 0 0
Lys 0 0 5 0 1 0 0 0
Arg 0 0 5 0 0 0 0 0
His 0 0 1 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
DPP7 9q34.3 ENSG00000176978 29952 DPP7 610537
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Dpp7 2:A3 ENSMUSG00000026958 83768 MGI:1933213