Summary for peptidase S29.001: hepacivirin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma


MEROPS Namehepacivirin
Other namesCpro-2, NS3 polyprotein peptidase (hepatitis C virus), NS3/4A protease (hepatitis C virus)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S29 >> Subfamily (none) >> S29.001
Holotypehepacivirin (hepatitis C virus), Uniprot accession P26664 (peptidase unit: 1027-1282), MERNUM MER0000295
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00397
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (4 cleavages)
PhysiologyContributes to processing of viral polyprotein.
Pharmaceutical relevanceDrug target for hepatitis C (Sperandio et al., 2002).