Summary for peptidase S32.001: equine arteritis virus serine peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Nameequine arteritis virus serine peptidase
Other names3CLSP, nonstructural protein 4, nsp4 protease
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S32 >> Subfamily (none) >> S32.001
Holotypeequine arteritis virus serine peptidase, Uniprot accession P19811 (peptidase unit: 1065-1261), MERNUM MER0000304
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00400
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (8 cleavages)
PhysiologyContributes to processing of viral polyprotein.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterny/-/-/EScissile bondGs/-/-/a (based on 15 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 0 1 10 1 0 0
Pro 0 0 1 0 0 0 0 1
Ala 0 1 1 0 0 1 1 4
Val 0 4 0 0 0 1 3 0
Leu 0 0 3 0 0 4 3 0
Ile 1 0 0 0 0 1 0 1
Met 3 0 0 0 0 0 0 0
Phe 1 3 1 0 0 0 1 0
Tyr 4 0 2 0 0 0 0 0
Trp 1 0 0 0 0 0 0 0
Ser 3 1 1 0 4 2 0 2
Thr 0 2 0 0 0 1 2 0
Cys 0 0 0 0 0 0 0 2
Asn 0 1 0 0 0 2 0 0
Gln 0 1 2 1 0 0 0 1
Asp 0 0 0 0 0 0 2 0
Glu 0 1 1 13 0 0 0 0
Lys 1 0 1 0 1 1 2 1
Arg 0 0 1 0 0 0 1 3
His 0 0 1 0 0 1 0 0