Summary for peptidase S53.004: kumamolisin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namekumamolisin
Other nameskumamolysin, pepstatin-insensitive acid proteinase (Bacillus), pepstatin-insensitive carboxyl proteinase (Bacillus)
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S53 >> Subfamily (none) >> S53.004
Holotypekumamolisin (Bacillus sp. MN-32) (peptidase unit: 187-548), MERNUM MER0019058
History Identifier created: MEROPS 5.3 (4 December 2000)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00411
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternVrf/eg/af/lfhScissile bondYl/lt/vp/- (based on 11 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 4 0 0 0 0 1 1
Pro 0 0 0 0 0 0 3 0
Ala 0 0 4 0 0 0 0 1
Val 5 1 0 1 0 1 4 0
Leu 0 0 0 4 2 5 0 1
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 1 0 4 3 0 0 0 0
Tyr 0 0 0 0 7 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 1 0 0 0 0 1
Thr 0 0 0 0 0 3 0 0
Cys 0 0 0 0 0 1 0 0
Asn 0 1 1 0 1 0 0 0
Gln 0 0 1 1 0 1 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 4 0 0 0 0 1 0
Lys 0 0 0 0 0 0 0 3
Arg 3 0 0 0 0 0 0 0
His 0 0 0 2 1 0 1 0