Summary for peptidase S53.006: physarolisin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Namephysarolisin
Other namesPhysarum aspartic proteinase [obs.], physaropepsin
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S53 >> Subfamily (none) >> S53.006
Holotypephysarolisin (Physarum polycephalum), Uniprot accession Q8MZS4 (peptidase unit: 173-575), MERNUM MER0004240
History Identifier created: MEROPS 5.8 (19 March 2002)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00412
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.103
EnzymologyBRENDA database
Proteolytic eventsCutDB database (10 cleavages)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/lScissile bond-/-/-/- (based on 11 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 0 2 2 1 2 2 1
Pro 1 0 0 0 0 0 0 1
Ala 1 0 1 1 0 0 1 0
Val 2 2 1 1 2 0 1 2
Leu 3 3 1 3 1 1 3 1
Ile 0 1 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 2 1 0 1 2
Tyr 1 1 1 0 1 2 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 1 0 0 1 0 0 0
Thr 0 0 0 0 0 0 1 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 1 1 2 1 1 2 1 1
Lys 0 0 0 0 0 0 0 0
Arg 0 1 0 0 1 2 1 1
His 1 0 1 0 0 1 0 0