Summary for peptidase S54.017: ROM4 peptidase (Plasmodium-type)

Summary Alignment Sequences Sequence features Distribution Literature Substrates


MEROPS NameROM4 peptidase (Plasmodium-type)
Other namesPfROM4 (Plasmodium sp.)
Name and HistoryThe infectious stage of the malaria parasite Plasmodium falciparum is the merozoite. To invade a host erythrocyte, the merozoite must first bind to host cell receptors. The surface of the merozoite has adhesins called Duffy binding ligand-erythrocyte binding proteins, of which the best characterized is erythrocyte binding antigen 175 (EBA-175). EBA-175 binds erythrocyte surface glycophorin A. The adhesin-glycophorin interaction has to be disrupted prior to host cell invasion, and EBA-175 is shed from the merozoite surface by PfROM4 (O'Donnell et al., 2006). Other adhesins are also shed by PfROM4 (Baker et al., 2006).
Domain architecture
MEROPS Classification
Classification Clan ST >> Subclan (none) >> Family S54 >> Subfamily (none) >> S54.017
HolotypeROM4 peptidase (Plasmodium-type) (Plasmodium falciparum) (peptidase unit: 438-653), MERNUM MER0026215
History Identifier created: MEROPS 7.60 (23 October 2006)
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
LocationPfROM4 is localized to the merozoite plasma membrane (O'Donnell et al., 2006).
Contributing authorsNeil D. Rawlings, InterPro, Proteins Cluster, EMBL European Bioinformatics Institute, Hinxton, Cambridgeshire, CB10 1SD, UK