Summary for peptidase T01.002: archaean proteasome, beta component

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namearchaean proteasome, beta component
Domain architecture
MEROPS Classification
Classification Clan PB >> Subclan PB(T) >> Family T1 >> Subfamily A >> T01.002
Holotypearchaean proteasome, beta component (Thermoplasma acidophilum), Uniprot accession P28061 (peptidase unit: 9-211), MERNUM MER0000548
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeThreonine
PeplistIncluded in the Peplist with identifier PL00415
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1
EnzymologyBRENDA database
Pathways KEGGProteasome
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 44 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 5 1 5 3 2 2 2 3
Pro 2 1 0 2 0 1 1 1
Ala 1 2 1 1 2 1 0 2
Val 6 1 4 7 3 2 3 3
Leu 5 12 5 7 4 4 10 3
Ile 3 3 1 3 2 5 3 5
Met 2 1 1 3 0 0 0 1
Phe 3 1 2 4 0 2 1 2
Tyr 1 2 0 0 2 2 2 0
Trp 0 1 0 0 1 0 2 0
Ser 2 2 2 4 5 3 5 3
Thr 0 2 2 1 3 2 1 6
Cys 0 0 0 0 0 0 0 1
Asn 1 2 2 0 1 1 3 0
Gln 2 0 3 2 1 2 1 1
Asp 1 2 1 3 3 2 3 2
Glu 2 5 6 2 8 6 2 4
Lys 2 4 6 1 4 5 1 3
Arg 2 2 2 1 1 2 2 1
His 2 0 0 0 0 1 0 0