Summary for peptidase T01.010: constitutive proteasome catalytic subunit 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameconstitutive proteasome catalytic subunit 1
Other namespeptidylglutamyl-peptide hydrolysing proteasome subunit, proteasome subunit beta 1, proteasome subunit beta 1c, proteasome subunit beta 6, PRE3 g.p. (Saccharomyces cerevisiae), proteasome subunit Y (Homo sapiens), proteasome subunit delta (Homo sapiens), PSMB6 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PB >> Subclan PB(T) >> Family T1 >> Subfamily A >> T01.010
Holotypeconstitutive proteasome catalytic subunit 1 (Saccharomyces cerevisiae), Uniprot accession P38624 (peptidase unit: 20-215), MERNUM MER0001645
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeThreonine
PeplistIncluded in the Peplist with identifier PL00418
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1
EnzymologyBRENDA database
Activity statushuman: active (Seemuller et al., 2004)
mouse: active (by similarity to other mammals)
PhysiologyOne of the peptidase units of the 20 S proteasome, and thus contributing to the major role of the proteasome in intracellular protein degradation.
Pharmaceutical relevanceProteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, and it is threrefore considered that inhibitors have the potential to be drugs for conditions such as cancer, rheumatoid arthritis and psoriasis that are characterised by these processes (Delcros et al., 2003; Elliott et al., 2003).
Pathways KEGGProteasome
Other databases TREEFAMhttp://www.treefam.org/family/TF106221
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterngyl/plvm/lamy/DelyScissile bond-/-/-/- (based on 15 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 0 0 0 0 0 0 0
Pro 0 5 0 0 1 0 2 1
Ala 0 0 4 0 2 0 0 0
Val 0 3 0 0 0 0 0 0
Leu 3 4 6 2 0 0 0 0
Ile 0 0 0 0 0 0 0 0
Met 0 2 2 0 2 1 0 1
Phe 0 0 0 0 0 0 1 0
Tyr 4 0 2 2 0 2 2 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 0 1 0 0
Cys 0 0 0 0 0 0 0 0
Asn 1 0 1 0 0 0 0 0
Gln 0 0 0 0 0 0 0 1
Asp 0 1 0 8 1 0 0 0
Glu 0 0 0 3 0 0 0 0
Lys 0 0 0 0 0 0 0 0
Arg 1 0 0 0 0 0 0 0
His 0 0 0 0 0 1 0 2
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PSMB6 17p13 ENSG00000142507 5694 PSMB6 600307
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Psmb6 11:B3 ENSMUSG00000018286 19175 MGI:104880