Summary for peptidase T01.011: proteasome subunit beta2c

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameproteasome subunit beta2c
Other namesconstitutive proteasome catalytic subunit 2, constitutive proteasome subunit beta 2c, proteasome subunit alpha (Homo sapiens), proteasome subunit beta 7, PUP1 g.p. (Saccharomyces cerevisiae), proteasome subunit Z (Homo sapiens), PSMB7 g.p. (Homo sapiens), trypsin-like proteasome subunit
Domain architecture
MEROPS Classification
Classification Clan PB >> Subclan PB(T) >> Family T1 >> Subfamily A >> T01.011
Holotypeproteasome subunit beta2c (Saccharomyces cerevisiae), Uniprot accession P25043 (peptidase unit: 30-232), MERNUM MER0000542
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeThreonine
PeplistIncluded in the Peplist with identifier PL00419
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1
EnzymologyBRENDA database
Activity statushuman: active (Seemuller et al., 2004)
mouse: active (by similarity to other mammals)
PhysiologyOne of the peptidase units of the 20 S proteasome, and thus contributing to the major role of the proteasome in intracellular protein degradation.
Pharmaceutical relevanceProteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, and it is threrefore considered that inhibitors have the potential to be drugs for conditions such as cancer, rheumatoid arthritis and psoriasis that are characterised by these processes (Delcros et al., 2003; Elliott et al., 2003).
Pathways KEGGProteasome
Other databases TREEFAMhttp://www.treefam.org/family/TF106222
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/t/rhkScissile bond-/vr/-/- (based on 14 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 1 0 0 1 0 1
Pro 3 0 0 0 1 0 0 0
Ala 1 1 1 1 1 0 1 0
Val 0 0 1 0 1 5 1 0
Leu 1 2 0 1 1 1 0 2
Ile 0 2 0 0 2 0 2 0
Met 0 0 0 1 0 0 1 2
Phe 0 0 1 0 0 0 0 0
Tyr 0 1 0 0 0 0 0 0
Trp 0 0 0 0 0 0 2 0
Ser 0 3 0 0 0 0 0 0
Thr 2 1 4 0 2 1 1 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 1 0
Gln 1 0 1 0 0 0 0 0
Asp 0 0 0 0 0 0 0 1
Glu 2 0 2 0 0 0 0 0
Lys 0 0 0 2 0 0 0 2
Arg 1 2 3 7 2 2 1 1
His 0 1 0 2 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PSMB7 9q34.11-q34.12 ENSG00000136930 5695 PSMB7 604030
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Psmb7 2:B ENSMUSG00000026750 19177 MGI:107637