Summary for peptidase T01.012: proteasome subunit beta5c

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameproteasome subunit beta5c
Other namesconstitutive proteasome catalytic subunit 3, chymotrypsin-like proteasome subunit, DOA3 g.p. (Saccharomyces cerevisiae), proteasome subunit beta5, proteasome subunit beta 5c, PRE2 g.p. (Saccharomyces cerevisiae), proteasome subunit epsilon (Homo sapiens), proteasome subunit MB1 (Homo sapiens), proteasome subunit X (Homo sapiens), PSMB5 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PB >> Subclan PB(T) >> Family T1 >> Subfamily A >> T01.012
Holotypeproteasome subunit beta5c (Saccharomyces cerevisiae), Uniprot accession P30656 (peptidase unit: 76-280), MERNUM MER0001516
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeThreonine
PeplistIncluded in the Peplist with identifier PL00420
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1
EnzymologyBRENDA database
Activity statushuman: active (Seemuller et al., 2004)
mouse: active (by similarity to other mammals)
PhysiologyOne of the peptidase units of the 20 S proteasome, and thus contributing to the major role of the proteasome in intracellular protein degradation.
Pharmaceutical relevanceProteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, and it is threrefore considered that inhibitors have the potential to be drugs for conditions such as cancer, rheumatoid arthritis and psoriasis that are characterised by these processes (Delcros et al., 2003; Elliott et al., 2003).
Pathways KEGGProteasome
Other databases TREEFAMhttp://www.treefam.org/family/TF106223
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/n/ylfScissile bond-/-/-/ep (based on 24 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 1 0 2 0 1 1
Pro 3 3 0 0 3 4 0 4
Ala 0 2 2 1 0 0 1 0
Val 0 0 3 1 3 0 0 0
Leu 2 4 3 6 0 0 0 1
Ile 2 0 0 2 0 2 0 1
Met 0 0 4 1 1 2 0 3
Phe 0 1 1 4 1 0 4 0
Tyr 3 1 0 7 0 2 2 0
Trp 2 0 0 0 0 0 0 0
Ser 0 1 1 0 2 0 2 0
Thr 1 4 0 0 0 2 2 1
Cys 0 0 0 0 0 0 0 0
Asn 1 2 5 0 1 0 1 1
Gln 0 0 0 0 0 0 0 0
Asp 0 2 0 2 3 1 0 0
Glu 0 0 0 0 1 0 1 4
Lys 0 0 0 0 0 0 2 0
Arg 3 1 0 0 1 1 0 0
His 1 1 3 0 0 2 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PSMB5 14q11.2 ENSG00000100804 5693 PSMB5 600306
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Psmb5 14:C1 ENSMUSG00000022193 19173 MGI:1194513