Summary for peptidase T02.002: isoaspartyl dipeptidase (threonine type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates

 

Names
MEROPS Nameisoaspartyl dipeptidase (threonine type)
Other namesasparaginase, asparaginase precursor, ASRGL1 g.p. (Homo sapiens), beta-aspartyl peptidase (eukaryote), beta-aspartyldipeptidase, EcAIII (Escherichia coli), hASNase3, human asparaginase 3, isoaspartyl aminopeptidase, isoaspartyl peptidase, Mername-AA125 peptidase, plant-type asparaginase, ybiK g.p. (Escherichia coli)
Domain architecture
MEROPS Classification
Classification Clan PB >> Subclan PB(T) >> Family T2 >> Subfamily (none) >> T02.002
Holotypeisoaspartyl dipeptidase (threonine type) (Escherichia coli), Uniprot accession P37595 (peptidase unit: 179-321), MERNUM MER0003338
History Identifier created: MEROPS 3.4 (5 November 1999)
Activity
Catalytic typeThreonine
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.5.1 () >> Peptidase 3.5.1.1
EnzymologyBRENDA database
Other databases TREEFAMhttp://www.treefam.org/family/TF323960
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/DScissile bond-/-/-/- (based on 17 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 4 1 0 0
Pro 0 0 0 0 0 0 0 0
Ala 0 0 0 0 2 2 0 0
Val 0 0 0 0 1 1 0 0
Leu 0 0 0 0 3 0 0 0
Ile 0 0 0 0 1 0 0 0
Met 0 0 0 0 1 0 0 0
Phe 0 0 0 0 1 0 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 1 0 0 0
Thr 0 0 0 0 1 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 17 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 0 1 0 0 0
Arg 0 0 0 0 0 0 0 0
His 0 0 0 0 1 0 0 0