Summary for peptidase C26.001: gamma-glutamyl hydrolase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namegamma-glutamyl hydrolase
Other namesconjugase, folate conjugase, gamma-Glu-X carboxypeptidase, lysosomal gamma-glutamyl carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, GGH g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PC >> Subclan PC(C) >> Family C26 >> Subfamily (none) >> C26.001
Holotypegamma-glutamyl hydrolase (Rattus norvegicus), Uniprot accession Q62867 (peptidase unit: 25-293), MERNUM MER0002464
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00113
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase 3.4.19.9
EnzymologyBRENDA database
Activity statushuman: active (Chave et al., 2004)
mouse: active (Priest et al., 1982)
PhysiologyHydrolyses poly-gamma-glutamyl forms of folic acid allowing cellular uptake.
Pathways KEGGFolate biosynthesis
Other databases TREEFAMhttp://www.treefam.org/family/TF323437
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
GGH 8q12.23-q13.1 ENSG00000137563 8836 GGH 601509
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ggh 4:A3 ENSMUSG00000028242 14590 MGI:1329035