Summary for peptidase M01.008: pyroglutamyl-peptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Substrates Inhibitors


MEROPS Namepyroglutamyl-peptidase II
Other namespyroglutamyl aminopeptidase II, thyrotropin-releasing hormone-degrading ectoenzyme, TRH-degrading ectoenzyme, thyroliberinase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.008
Holotypepyroglutamyl-peptidase II (Rattus norvegicus), Uniprot accession Q10836 (peptidase unit: 369-592), MERNUM MER0001701
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00127
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase
EnzymologyBRENDA database
Activity statushuman: active (Bauer, 2004)
mouse: active (Mayas et al., 2000)
PhysiologyEctoenzyme with possible role in destruction of TRH.
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
TRHDE 12q15-q21 ENSG00000072657 29953 606950
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Trhde 10:D2 ENSMUSG00000050663 237553 MGI:2384311