Summary for peptidase M03.001: thimet oligopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namethimet oligopeptidase
Other namesendo-oligopeptidase A, endopeptidase 24.15, oligopeptidase A, Pz-peptidase, THOP1 g.p. (Homo sapiens), TOP, soluble metalloendopeptidase
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M3 >> Subfamily A >> M03.001
Holotypethimet oligopeptidase (Rattus norvegicus), Uniprot accession P24155 (peptidase unit: 2-687), MERNUM MER0001149
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00136
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.15
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
Activity statushuman: active (Barrett & Chen, 2004)
mouse: active (by similarity)
PhysiologyProposed for a role in pericellular destruction of several bioactive peptides, but is primarily located in the cytosol where it plays an important role in degrading peptides released by proteasomes and is a significant factor limiting the extent of antigen presentation (York et al., 2003).
Pathways KEGGAfrican trypanosomiasis
KEGGRenin-angiotensin system
Other databases TREEFAMhttp://www.treefam.org/family/TF300459
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternG/Fk/spg/PfrScissile bondFsr/rp/Q/- (based on 124 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 65 2 16 1 6 3 1 2
Pro 5 6 18 57 0 31 2 1
Ala 1 5 2 4 3 3 1 2
Val 1 1 4 1 0 3 2 0
Leu 0 2 3 6 1 5 10 0
Ile 0 2 1 0 4 5 3 3
Met 2 0 0 1 0 0 2 1
Phe 3 53 7 20 56 2 14 4
Tyr 1 3 0 2 2 3 4 1
Trp 0 0 0 0 1 0 0 0
Ser 2 3 56 2 20 4 2 1
Thr 0 1 2 0 1 0 1 4
Cys 0 0 0 0 0 0 0 0
Asn 11 1 1 3 2 1 2 4
Gln 1 3 4 1 2 2 68 5
Asp 3 1 1 4 2 1 1 1
Glu 1 1 1 1 1 1 4 2
Lys 2 14 2 2 3 2 0 0
Arg 5 7 3 17 19 55 5 9
His 1 2 2 2 1 3 0 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
THOP1 19q13.3 ENSG00000172009 7064 THOP1 601117
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Thop1 10 ENSMUSG00000004929 50492 MGI:1354165